Comparing multiple miRNA target prediction programs including, miRDB, miRWalk and DIANA, we identified Pellino 3 (PELI3) as a putative target of miR-744-5p and demonstrated significantly reduced (P ≤ 0.01) expression of the gene in PECs from pSS patients compared to healthy controls (Fig. 1C). Here, PELI3 is linked to peeling skin syndrome.