CD274 and lung adenocarcinoma: Though in previous studies16,17, the tumor-expressing PD-L1 was always a poor prognostic factor for lung adenocarcinoma, we also did not find a close relation between the PD-L1 expressed in tumor (T-PD-L1) and VECs (VEC-PD-L1) (r = 0.118 p = 0.227) (Fig. 1d).