KRAS, RAC1 and MDM2 were the genes most frequently affected by copy gain (5+ copies per tumour in 86%, 24% and 21%, respectively) whilst CBL, TP53 and CREBPP were the genes most frequently affected by copy loss (0 or 1 copies in 20%, 5% and 4%, respectively). This evidence concerns the gene TP53 and neoplasm.