In summary, we demonstrate via multifactorial analysis adjusted for clinical and technical confounding factors, that there is significant difference between platinum-sensitive and platinum-resistant tumours in frequency of (i) KIT mutation, (ii) TP53 mutation, (iii) mutations in WNT/CTNNB1 signalling genes, and (iv) mutational burden of nonsynonymous small variants. The gene discussed is TP53; the disease is neoplasm.