In patients developing graft versus host disease (GVHD) after hematopoietic cells transplantation (HCT), excessive increases of the sST2 level reduce the pool of IL-3318 for activation of the ST2/IL-33 axis in Th2, ILC2, and Tregs cells that leads to unrestrained inflammation in early GVHD progression19–21. This evidence concerns the gene IL33 and graft versus host disease.