IL1R1 and lobular neoplasia: One of these pathways was enriched for several molecules involved in inflammation, including IL1R1, IL1RAP, IL1RAPL2, IL15RA, IL17F, IL18R1, E-selectin, TLR2, CD86, and several signaling molecules, including MAKAPK2, MAPKAPK3, and MAPKAPK5, all of which were significantly elevated in the urine of patients with active LN, as indicated by the pink-colored nodes in Fig. 1b.