PDCD1LG2 and diffuse large B-cell lymphoma: PD-1 expression in T-cells was associated with significantly poorer OS and PFS, whereas CTLA-4 expression in T-cells and PD-L2 expression in B-cells were associated with significantly better OS and PFS, respectively (Fig. 4c, Supplementary Fig. 4), resembling the prognostic impact of immune checkpoint expression in DLBCL–NOS46.