PD-1 expression in T-cells was associated with significantly poorer OS and PFS, whereas CTLA-4 expression in T-cells and PD-L2 expression in B-cells were associated with significantly better OS and PFS, respectively (Fig. 4c, Supplementary Fig. 4), resembling the prognostic impact of immune checkpoint expression in DLBCL–NOS46. This evidence concerns the gene CTLA4 and diffuse large B-cell lymphoma.