Compared with implanted wild-type GFP+MSCs or control vector-expressing GFP+MSCs groups, the implantation of CXCR7-expressing GFP+MSCs promoted vascularization, endothelial differentiation of GFP+MSCs, and vessel elongation (Fig. 5i–n), indicating CXCR7 gain-of-function promotes vasculogenesis by MSCs and its therapeutic impact on ischemic diseases. The gene discussed is ACKR3; the disease is ischemic disease.