PARK7 and colorectal carcinoma: In addition, we found that a synthetic antifungal agent (Ciclopirox olamine, CPX), which has been used for treating advanced solid tumors in a United States multi-center first-in-human Phase 1 clinical trial (NCT03348514), exhibits considerable anti-CRC efficacy by targeting DJ-1 (Zhou et al., 2019), suggesting the potential of targeting DJ-1 for treating CRC.