DJ-1 can promote tumor initiation and progression through multiple pathways such as activating HIFα, MEK/ERK, Akt/mTOR, NF-κB signaling pathway, or inhibiting JNK, p53 and ASK1 (Davidson et al., 2008; He et al., 2012; Kim et al., 2005; Sitaram et al., 2009). Here, MAP3K5 is linked to neoplasm.