In addition, activation of GR signaling by dexamethasone has been shown to increase expression of C/EBPα in hepatoma cells (Cram et al., 1998) and the GR itself can interact directly with C/EBPα and increase its activity in different cell types (Rüdiger et al., 2002; Muratcioglu et al., 2015). The gene discussed is NR3C1; the disease is hepatocellular carcinoma.