The degree of elevation of IL-4 (quintile) had the highest relative-risk ratio of 2.5 for RAP (p=0.001, logistic regression analysis after age adjustments), followed by 2.1 for typical AMD (p=0.000) and 1.7 for PCV (p=0.000) (Table 2). This evidence concerns the gene LRPAP1 and age-related macular degeneration.