In the present study, we investigated the influence of rs2736100 and rs12696304 variants on primary GN/CKD/ESRD risk, and the obtained results demonstrate significantly higher frequencies of the rs12696304 G allele and GG genotype in patients than in healthy controls, which indicate that the TERC rs12696304 G allele serves as a biomarker to GN/CKD/ESRD risk. The gene discussed is TERC; the disease is chronic kidney disease.