Further, intraperitoneal administration of an anti-apoE antibody into AD mice improves cognitive function and reduces brain Aβ load [17], and decreasing APOE expression by antisense oligonucleotides significantly alleviates Aβ pathology in amyloid mice homozygous for the APOE3 or APOE4 allele [18]. Here, APOE is linked to amyloidosis.