In this study, we identified CYP1A1 as a critical regulator of inflammatory responses and phagocytosis in sepsis and described two novel CYP1A1-invovled signalling pathways, CYP1A1–12(S)HETE−JNK − AP-1 and CYP1A1-SR-A, that may be promising targets for treating sepsis or other inflammatory diseases. This evidence concerns the gene JUN and Sepsis.