To specifically assess the involvement of CYP1A1 in sepsis, recombinant CYP1A1-expression adenovirus (Ad-CYP1A1), hydroxylase-deficient CYP1A1 adenovirus (Ad-CYP1A1m) and negative control adenovirus (Ad-NC) were constructed and transfected into WT PMs (Supplemental Figure 6 A) and then evaluated the effects of these cells on the mortality of E. coli- or CLP-induced septic WT mice by adoptive cell transfer (Supplemental Figure 6 B). This evidence concerns the gene CYP1A1 and Sepsis.