In HaCaT cells, there was a H3K27ac peak at the KLF4 promoter that interacted with several regions across the gene desert including psoriasis-associated enhancers 3 and 4 and at the previously published interacting region from the breast cancer study in both unstimulated and stimulated HaCaT cells (Fig. 5) [17]. Here, KLF4 is linked to breast cancer.