The CHi-C data showed multiple, robust interactions between the psoriasis-associated regions at the LCE genes, including from within the 32-kb LCE3C/B-del region, and genes downstream in the EDC that included IVL, LOR, PRR9 and SPRR genes, over a distance of ~ 600 kb (Fig. 3b). The gene discussed is IVL; the disease is psoriasis.