Importantly, CRISPRa of the psoriasis-implicated enhancer in this keratinocyte cell line not only resulted in an increase in KLF4 expression, but a differential expression of 3 keratin genes (keratin 4, 13 and 15), confirming the importance of this enhancer and the KLF4 gene in skin cell function. This evidence concerns the gene KLF4 and psoriasis.