To elucidate the cell proliferation mechanism(s) in FAT4 siRNA treated gastric cancer cells Ma et al. performed a flow cytometry to reveal an increase in the number of cells in S and G2/M phases, as well as an upregulation of proliferation-associated markers such as cyclin D1, c myc [21] in gastric cancer, and cdk 1 and cdk 2 [18] in endometrial cancer. Here, FAT4 is linked to endometrial cancer.