Recently, Ehmsen et al. reported that DHCR7, LSS, FDFT1, EBP, NSDHL, and HMGCS1 directly involved in the enzymatic catalytic steps and CYB5R3 functions as a reductase enzyme in the ER membrane were elevated in mammospheres to reveal stem like features, and suggested the cholesterol biosynthesis pathway is associated with breast cancer stem cell propagation [7]. The gene discussed is HMGCS1; the disease is breast cancer.