The lower mean LH concentrations and decreased LH pulse amplitude and activity over the luteinized granulosa/theca cells in addition to an upregulation of the apoptosis of granulosa cells induce the process of luteolysis early in the luteal phase, which seems to be key factors for OHSS prevention after GnRHa trigger (20,21). The gene discussed is PLOD1; the disease is ovarian hyperstimulation syndrome.