Babaian et al., analyzed RNA-seq datasets from nine Hodgkin lymphomas (HL), finding that proinflammatory transcription factor IRF5 was upregulated in HL-derived cell lines due to the transcriptional activation of the retroviral LOR1a LTR as regulatory enhancer (Figure 3B) [115]. The gene discussed is IRF5; the disease is Hodgkins lymphoma.