However, studies have shown that in order to compensate for the loss of sclerostin in sclerosteosis and Van Buchem disease patients, as well as in Sost KO mice, expression of other Wnt inhibitors such as Dickkopf-related protein 1 (DKK1) are upregulated [168,169]. This evidence concerns the gene DKK1 and hyperostosis corticalis generalisata.