MFGE8 and mucopolysaccharidosis: Plexin-related changes have been connected to various impairments in functions of central nervous system [75,76,77,78] which are also common in some MPS types, as indicated in Figure 5C. Dysregulation of the MFGE8 gene has been linked to neurodegenerative processes dependent on the accumulation of amyloid [79,80,81,82], and a similar phenomenon has been described in MPS [83,84,85], which is presented in Figure 5D.