It is also very interesting that the necrosis observed after myocardial ischemia or stroke [38,39] occurs in response to a lack of oxygen to the mitochondria, suggesting that MD, similarly to PD and TFLD-Tau and other conditions such as myocardial infarction or ischemic stroke, could occur through the same calcium overload process, which leads to necrosis. Here, MAPT is linked to ischemic stroke.