It is also very interesting that the necrosis observed after myocardial ischemia or stroke [38,39] occurs in response to a lack of oxygen to the mitochondria, suggesting that MD, similarly to PD and TFLD-Tau and other conditions such as myocardial infarction or ischemic stroke, could occur through the same calcium overload process, which leads to necrosis. This evidence concerns the gene MAPT and stroke disorder.