Since the decreasing importance of tau protein and amyloid in the etiology of Alzheimer’s disease is proposed [158,159,160] and it is believed that the deposition of tau protein and amyloid is not the reason of Alzheimer’s disease, as presented in the NIA-AA Research Framework: towards the true explanation of Alzheimer’s disease [161], in this situation we need more innovative investigation in this field. Here, MAPT is linked to early-onset autosomal dominant Alzheimer disease.