MAPT and early-onset autosomal dominant Alzheimer disease: It seems that post-ischemic brain injury promotes the development of irreversible neurodegeneration of the Alzheimer’s disease type with massive neuronal loss [1,2], neuroinflammation [20,22,23], changes in white matter with general brain atrophy [1,2,26,27], and accumulation of amyloid [2,43,52] and dysfunctional tau protein [3,61,63,117].