The conclusions presented from the exploration of Alzheimer’s disease-related tau protein and amyloid and their genes in ischemic brain injury, which are partly associated with neuronal death by the development of neurofibrillary tangles and amyloid plaques (Figure 1, Figure 2 and Figure 3), are key to improving treatment of irreversible ischemic neurodegeneration [155,156,157]. Here, MAPT is linked to early-onset autosomal dominant Alzheimer disease.