Although the role of ischemia in amyloid changes and tau protein hyperphosphorylation is generally complex and requires further research, and amyloid and tau protein are a relatively underestimated pathological factors in the brain after ischemia in animals and humans, we have reason to believe that determining the role of these molecules in brain ischemia can help us understand the basis for developing a new treatment goals for ischemic stroke in a human clinic [155,156,157]. Here, MAPT is linked to ischemic stroke.