In univariate analysis, older age, male, HBsAg seropositivity, low serum albumin, high serum bilirubin, high serum alanine aminotransferase (ALT), thrombocytopenia, prolonged prothrombin time (PT), RI, higher AFP level, multiple tumors, larger tumor size, presence of vascular invasion, distant metastasis, presence of ascites, poor performance status, and ALBI grade 2 and 3 were all associated with decreased long-term survival. This evidence concerns the gene F2 and Thrombocytopenia.