In univariate analysis, serum HBsAg seropositivity, low serum albumin level, high serum bilirubin level, high serum ALT level, thrombocytopenia, PT, higher serum AFP, multiple tumors, larger tumor size, presence of vascular invasion, distant metastasis, presence of ascites, poor performance status, and ALBI grade 2 and ALBI grade 3 were linked with decreased survival in HCC patients with RI. The gene discussed is AFP; the disease is hepatocellular carcinoma.