Patients with RI more often had a lower serum albumin level (p < 0.001), higher serum bilirubin level (p = 0.003), lower serum α-fetoprotein (AFP) level (p = 0.004), larger tumor size (p = 0.026), more advanced stage cirrhosis (p < 0.001), higher prevalence of DM (p < 0.001), poor performance status (p < 0.001), more advanced BCLC stage (p < 0.001), and lower rate of curative resection (p < 0.001) in comparison to patients without RI. The gene discussed is ALB; the disease is Cirrhosis.