There is also evidence that the transcription factor GLIS2 regulates Wnt4 expression, with homozygous mutant GLIS2-/- mice and GLIS2-knockdown IMDC3 cells showing upregulated Wnt4 expression and GLIS2 mutations linked to Nephronophthisis 7 in humans and mice [60]. The gene discussed is WNT4; the disease is nephronophthisis.