Interestingly, an upregulation of SCRIBBLE was observed in human ARPKD kidney biopsies; likewise, in Pkhd1 knockdown mIMDC3 cells, a 60% increase in Scribble mRNA expression was detected, suggesting links between Scribble and Fibrocystin in ARPKD [47]. This evidence concerns the gene PKHD1 and autosomal recessive polycystic kidney disease.