High expression of CUL4A, ERCC1, and ERCC5 correlated with low histologic grade in the wholes series and this association was also statistically significant in the experimental arm, at least for CUL4A and ERCC1. Similar to our data, high expression of CUL4A or ERCC1 had been associated with better outcome in sarcomas [8,16,32,33]; however, and to our knowledge, no correlation between CUL4A or ERCC1 expression levels and histologic grade had been reported in STS. This evidence concerns the gene CUL4A and telomere syndrome.