In this study, we identified and replicated a specific association between active TB disease and PARP9/miR-505 hypomethylation or RASGRP4/GNG12 hypermethylation, as well as between clinical phenotypes of active TB and MRPS18B/RPTOR hypomethylation in PBMC DNA from patients with active pulmonary TB and HS. This evidence concerns the gene RPTOR and pulmonary tuberculosis.