PARP9 and tuberculosis: DNA methylation levels over +1741 CpG site of the PARP9 gene was also further decreased in TB patients without sputum AFB smear/Mtb culture conversion to negative after 2-month anti-TB treatment versus that in those with sputum conversion to negative at month 2 (54.72 ± 14.91 versus 62.29 ± 11.17 %, adjusted p = 0.03) or HS (adjusted p = 0.05) (Figure 2a).