Moreover, we found a specific association of aberrant DNA methylation levels over the WIPI2, MRPS18B, FOXO3, and GNG12 genes with lower one-year survival in TB patients, and a specific DNA de-methylation change of the PARP9, RASGRP4, WIPI2, and FOXO3 genes in response to in vitro Mtb-specific antigen stimuli. Here, WIPI2 is linked to tuberculosis.