DNA methylation levels over -1194 CpG site of the RASGRP4 gene (62.1 ± 13.8 versus 53.1 ± 11.5%, adjusted p = 0.01, Figure 2c) as well as over +1434 CpG site of the GNG12 gene (11.4 ± 1.9 versus 9.1 ± 3.8%, adjusted p = 0.001, Figure 2d) were increased in TB patients at diagnosis versus HS. This evidence concerns the gene RASGRP4 and tuberculosis.