In lung cancer, garcinol induces apoptosis by impairing phosphorylation of low-density lipoprotein receptor-related protein 6 (LRP6) and down regulating expression of Axin2, β-catenin, cyclin D1, and disheveled segment polarity protein 2 (Dvl2) in H441 and A549 NSCLC cell lines. This evidence concerns the gene DVL2 and lung cancer.