Destabilization of ADA3 by garcinol treatment in HER2+ breast cancer cells leads to cell cycle inhibition and apoptosis via receptor tyrosine kinase (RTK)-AKT-p300-ADA3 signaling pathway and supported with accumulation of p27, reduction in pH(S10), proliferation cell nuclear antigen (PCNA), and induction of cleaved poly(ADP-ribose) polymerase (PARP) [44]. Here, PCNA is linked to breast carcinoma.