Additionally, oral iron chelator deferiprone has a renoprotective effect by decreasing ROS levels and reducing inflammation and fibrosis markers, such as NF-κB, CCL2, MMP-9, tissue-specific inhibitor of metalloproteinase (TIMP)-1, cyclo-oxygenase (COX)-2, and nitrotyrosine in kidney tissues in high-carbohydrate-fat diet and STZ-induced DN rats [57]. This evidence concerns the gene CCL2 and liver dysplastic nodule.