The vascular smooth muscle cell and mesangial cell-specific overexpression of Nox5 isoform of NADPH oxidase leads to increased glomerular ROS production, glomerulosclerosis, mesangial expansion, and ECM accumulation with increased macrophage infiltration and CCL2 levels in a mouse model of DN [56]. The gene discussed is FMO5; the disease is liver dysplastic nodule.