VTCN1 and non-small cell lung carcinoma: Zhen-Ye Li et al. [170], evaluated B7-H4 expression in brain metastases from NSCLC, reporting that patients whose metastases were strongly positive for B7-H4 expression had a shorter median OS compared to patients with low expression of B7-H4 (11.4 months vs. 26.2 months; p = 0.002) [170].