As an example, among 76 NSCLC patients evaluated during their antineoplastic treatment, PD-L1 was tested by IHC on tumor cells and compared before and after treatment: in 29 cases PD-L1 had a major change (i.e., turned from negative to ≥ 1% or ≥ 50%, and vice versa) [23]. The gene discussed is CD274; the disease is neoplasm.