CD274 and melanoma: [160] This protein can up-regulate the expression of PD-L1; indeed, in a recent study including 21 melanoma patients and 17 NSCLC patients treated with Nivolumab, it has been demonstrated that an high expression of IFN-g mRNA was associated with longer PFS and OS in both groups even though the OS difference in the NSCLC patients was not statistically significant.