EGFR and breast cancer: Interestingly, an extensive study of growth factor-associated gene expression changes in doxorubicin and docetaxel-resistant human breast cancer MDA-MB-468 cells showed a strong induction (~40-fold increase) of TGFB1 expression along with higher transcript expression of EGFR, FGFBP3, and higher TGFBR1 expression at the protein level.