Notably, the expression of PCA3 in PCa tissue was significantly lower in patients who had died of their tumor (AUC of 0.98 [0.96–1] and 0.98 [0.95–1] for TAPIR-1 and -2, respectively versus AUC of 0.80 [0.68–0.91] for PCA3). Here, PCA3 is linked to posterior cortical atrophy.