We found that the knockdown of TAPIRs leads to the suppression of genes essential for the DNA-damage response, as there are BRCA1 (breast cancer 1, early-onset), CHEK1 (Checkpoint kinase 1), CLSPN (Claspin), and genes encoding proteins of the Fanconi anemia pathway [49,50,51,52]. This evidence concerns the gene CLSPN and Fanconi anemia.