EGF and neoplasm: Different factors involved in tumor progression, including hypoxia, activated Ras, and a variety of growth factors—especially epidermal growth factor (EGF), fibroblast growth factor (FGF), platelet growth factor (PDGF), and TNF-α—increase intracellular ROS by activating the primarily membrane-bound family of the NADPH oxidase (NOX) enzymes [30,31].