For example, the expression of Sirtuin 4 (SIRT4) in B cell lymphoma, which is a mitochondrial-localized tumor suppressor protein that inhibits a glutamate-to-α-KG conversion, was associated with a decreased glutamine uptake and cellular growth; conversely, its loss increased glutamine consumption and hastened tumorigenesis [133]. Here, SIRT4 is linked to B-cell non-Hodgkin lymphoma.