Mitochondrial biogenesis and OXPHOS have also been suggested to support metastatic dissemination, as demonstrated when the peroxisome proliferator-activated receptor gamma coactivator-1 alpha (PGC-1α) was silenced in breast cancer models [163]; PGC-1α is a central regulator of mitochondrial biogenesis whose levels are often associated with tumor reliance on mitochondrial respiration (for further details refer to [164]). This evidence concerns the gene PPARGC1A and breast carcinoma.