In addition to causing genetic modifications, ROS have also been associated with epigenetic alterations that favor oncogenic transformation; indeed, a ROS-induced hypermethylation of the promoter region of tumor suppressor genes has been shown to promote carcinogenesis, as exemplified in liver cancer, where hepatocellular carcinoma (HCC) cells exposed to H2O2 had increased hypermethylation levels of the promoter region of the E-cadherin gene (a hallmark of an epithelial-to-mesenchymal transition (EMT) that is lost during this process), leading then to its down-regulation [115]. The gene discussed is CDH1; the disease is hepatocellular carcinoma.