PPARGC1A and neoplasm: Moreover, rotenone, which is a mitochondrial complex I inhibitor, mirrored the PGC-1α silencing effects on tumor cells, with reduced mitochondria respiration and invasive properties, thereby pinpointing the crucial role of mitochondrial-derived ATP on the capacity of tumor cells to be invasive; these results brought newfound significance to the role of PGC-1α in supporting tumor metastasis [163].