CBS and neoplasm: With respect to the inhibitory effect of AOAA on cancer cell metabolism, the two best supported theories relate to inhibition of tumor cell GOT1 and glutaminolysis and inhibition of the mitochondrial effects of CBS-derived H2S. Since both pathways, ultimately, culminate on cellular bioenergetic processes, it is possible that these two pathways work in an additive or synergistic fashion (Figure 12).