In addition, in a mouse model of Down syndrome (Dp(17Abcg1-Cbs)1Yah), a mouse which carries an extra copy of the mouse chromosome 17 fragment that encodes CBS—as well as several additional genes), neurobehavioral deficits were also observed, and they were ameliorated by CBS silencing [259] (as well as by the action of disulfiram, which is generally viewed as an aldehyde dehydrogenase inhibitor, but which was identified, in the same study, based on phenotypical screens, as a cell-based inhibitor of CBS activity; see below). This evidence concerns the gene CBS and Down syndrome.