It is also interesting to note that in a study conducted in a general pediatric population, the c.844_845ins68 CBS allele (a polymorphism of CBS which leads to alternative splicing, but still permits synthesis of normally spliced mRNA) was significantly underrepresented in children with high IQ [173], while the same allele was significantly overrepresented in diabetic patients presenting with mild cognitive impairments [174]. Here, CBS is linked to Cognitive impairment.