Concerning IBD (Figure 2), an increase in the level of exosomes containing annexin A1, a protein that stimulates intestinal mucosa wound repair in a murine model of colitis [88] and promotes the resolution of inflammation by binding to formyl peptide receptors expressed on immune [89] and epithelial [90] cells, was observed in the serum of IBD patients compared to healthy subjects and may be used as a potential biomarker of intestinal mucosa inflammation [15]. Here, ANXA1 is linked to inflammatory bowel disease.