SKP2 and lung cancer: It inhibits cell growth and induces apoptosis by altering the expression of GSK-3β, the anti-apoptotic X-linked inhibitor of apoptosis protein (XIAP) and induced myeloid leukemia cell differentiation protein (MCL1) molecules and degradation of other molecules such as c-MYC, S-phase kinase-associated protein 2 (SKP2), histone deacetylase 1(HDAC1) and HDAC2 in certain cell types such as the lung cancer A549 cell line [102].