STAT3 and cancer: Muscle wasting during cancer increases systemic inflammation [33,34] and inflammatory tumorkines, such as IL-6, monocyte chemoattractant protein 1 (MCP-1), and regulated on activation, normal T cell expressed and secreted (RANTES), activate transcriptional factors, such as signal transducer and activator of transcription 3 (STAT3) and CCAAT-enhancer-binding protein β (C/EBPβ) [34,35,36,37].