However, although STAT3 has been reported to promote catabolic processes in the muscle during inflammation-induced cachexia [34], in C2C12 cells, STAT3 has been shown to regulate both proliferation and differentiation [73,74] and indeed p-STAT3 and STAT3 were elevated in myotubes when compared to myoblasts in the present study. Here, STAT3 is linked to Cachexia.