BRCA1 [6] and BRCA2 [7] are the genes best known for their involvement in BC predisposition in both females and males [8], with an MBC risk that has been estimated of 1.2% and 6.8% by the age of 70 for carriers of variants in BRCA1 and BRCA2, respectively [9]. The gene discussed is BRCA1; the disease is breast cancer.