In addition to BRCA1/2 variants, we identified four PVs in PALB2, ATM, CHEK2 and RAD51C, classified as moderate penetrance genes for the risk of BC and/or OC [5] and two LPVs in unexpected genes, such as BAP1 and EGFR. The patients in which we detected PVs/LPVs in genes other than BRCA1/2 have an average age at MBC onset (55.8 years), that is lower than the age of MBC patients without PVs/LPVs (64.9 years) and also than the age of MBC patients with BRCA1/2 PVs (62.5 years). This evidence concerns the gene CHEK2 and breast cancer.