Conversely, Soussi et al. described the basal accumulation of p62 in obese subcutaneous adipocytes compared to lean adipocytes, but when assaying the autophagic flux, no changes in LC3 accumulation was seen, indicative of an already altered autophagic clearance in obesity [181]. Here, MAP1LC3A is linked to obesity due to melanocortin 4 receptor deficiency.