Various synaptic proteins, such as SNAP-25, synaptophysin, rab 3A (presynaptic protein), PSD-95, synaptopodin (postsynaptic protein), synapsin 1, and chromogranin B (synaptic vesicle proteins), have been reported to be significantly reduced in the brains of patients with AD [91,107,162,163,164]. The gene discussed is SNAP25; the disease is Alzheimer disease.