HMGA2 and head and neck squamous cell carcinoma: For instance, let-7c was shown to suppress EMT and proliferation of head and neck squamous cell carcinoma by targeting HMGA2 and IGF1R [163], while let-7a knockdown exhibited an analogous inhibitory function in nasopharyngeal carcinomas induced by HMGA2 expression, decreasing HMGA2 and the expression of EMT marker genes Snail, Slug, and vimentin [164].