In uterine leiomyomas, the inverse physiological relationship between let-7 and HMGA2 also persists such that large leiomyomata were observed to express low levels of let-7 and high levels of HMGA2, while small leiomyomata expressed high levels of let-7 and low levels of HMGA2 [94]. This evidence concerns the gene HMGA2 and Uterine leiomyoma.