Specific small non-coding circular RNAs (circNSUN2) promotes EMT and human and mouse colorectal cancer (CRC) cell metastasis by stabilizing high levels of cytoplasmic HMGA2 RNA-protein interactions in a circNSUN2/IGF2BP2/HMGA2/ complex and activating the HMGA2 pathway [178]. The gene discussed is HMGA2; the disease is colorectal carcinoma.