In mechanistic studies using adipogenic progenitor cells of lipomas and uterine leiomyomas, a p14Arf-MDM2-TP53-let-7 network stabilized HMGA2 expression, lowering the tendency for malignant transformation while maintaining stem-like proliferative characteristic of benign mesenchymal tumor cells [26]. The gene discussed is HMGA2; the disease is Uterine leiomyoma.