LIN28A and neoplasm: Additionally, by repressing let-7, LIN28A/B indirectly upregulates cell cycle regulators targeted by let-7 such as cyclinD1/2, CDK6, CDC34, CDC25A, and TRIM71, and cell proliferation pathway targets PI3K/AKT, MAPK, MYC, RAS and BLIMP1 leading to aberrant proliferation of tumor cells [99].