Compared to matched normal tissues, our results reveal significant downregulation of let-7a expression and upregulation of Lin28a, Lin28b and Igf2bp2 in all mesenchymal tumors assessed including hepatic hemangiosarcomas, foot lymphomas, and hemangiomas, and in pulmonary adenomas by RT-PCR (unpublished data). This evidence concerns the gene LIN28A and mesenchymal cell neoplasm.