Chromosomal rearrangements and intragenic chromosomal breakpoints within the region 12q14~15 leading to the formation of truncated HMGA2 transcripts lacking the 3’ untranslated region (UTR) of HMGA2 mRNA have been observed in many benign mesenchymal tumors, including some uterine leiomyomata and pulmonary chondroid hamartomas [62,63]. This evidence concerns the gene HMGA2 and neoplasm.