In mechanistic studies using adipogenic progenitor cells of lipomas and uterine leiomyomas, a p14Arf-MDM2-TP53-let-7 network stabilized HMGA2 expression, lowering the tendency for malignant transformation while maintaining stem-like proliferative characteristic of benign mesenchymal tumor cells [26]. This evidence concerns the gene HMGA2 and uterine corpus leiomyoma.