MMP2 and central nervous system cancer: As an example, in gliomas, HMGA2 was shown to form a complex with histone lysine acetyltransferase GCN5 and bind to AT-rich promoter region of matrix metalloproteinase 2 (MMP2), catalyzing the histone acetylation and chromatin conformational remodeling of the promoter that induced gene transcription and invasive phenotype of glioblastoma cells [111].