Given that HMGA2 expression dynamics are functionally superimposable to mammalian embryogenic differentiation paradigms, genetic anomalies at the HMGA2 locus during this tissue maturation period could account for anomalous cell fate specification, which could lead to multi-systemic neoplasms, determining tissues that would become tumorigenic, and the timing of tumor ontogeny. The gene discussed is HMGA2; the disease is neoplasm.