However, an increasing expression of HMGA2 was observed to be distributed from non-neoplastic, well-differentiated centers of human colorectal tumors, human squamous carcinoma, and MMTV-Wnt1 transgenic mice mammary tumors towards the extremity invasive front where the overwhelming majority of tumor cells were HMGA2-positive [15,150]. This evidence concerns the gene HMGA2 and squamous cell carcinoma.