TSC2 and lymphangioleiomyomatosis: In our laboratory, we focused on the mechanisms of HMGA2 in LAM pathogenesis, and established that although HMGA2 was mis-expressed in 100% of tumors resected from LAM patients in our studies and from Tsc2+/− mice, an established animal model for LAM [14,146], Hmga2−/−Tsc2+/− mice exhibited minimal renal (epithelial) tumors and no extra-renal (mesenchymal) tumors) [146].