High levels of HMGA2 transcription in larger leiomyomata could encode more 3’ UTR binding sites to soak up available mature let-7 miRNA limiting the repressive and degradative function of let-7 on HMGA2 expression [40,41], and allowing for greater rates of tumorigenesis compared to smaller sized uterine fibroids. The gene discussed is HMGA2; the disease is uterine corpus leiomyoma.