HMGA2 and mesenchymal cell neoplasm: Some of these transcripts derive from chromosomal translocations at 12q13–15 which truncates the human HMGA2 open reading frame (ORF) resulting in loss of its C-terminus and/or fusion to partner ectopic sequences [38,39], while in other mesenchymal tumors, intact ORF have been resolved but with truncated 3’ untranslated region (UTR) which encodes binding sites for let-7, a negative regulator of HMGA2 expression [40,41].