Similar results were obtained with a canine B-cell lymphoma cell line: Parental CLBL-1 cells express low levels of Pgp (MAF = 0.16 ± 0.03), which were significantly increased after 6 rounds of doxorubicin treatment (MAF = 0.39 ± 0.05), resulting in the increased doxorubicin resistance of the cells. Here, PGP is linked to B-cell non-Hodgkin lymphoma.