For instance, the Ségui’s laboratory reported that TNFR1 mediates the Activation-Induced Cell Death (AICD) of CD8+ melanoma-specific tumour infiltrating lymphocytes (TILs) [93] and that combining anti-TNF and anti-PD-1 promotes the regression of murine melanoma [94]. The gene discussed is TNFRSF1A; the disease is melanoma.