CHOP-dependent TRAIL-R2 up-regulation and ensuing TRAIL-R2-mediated cell death has been observed in multiple human cancer cell lines, such as colon cancer, prostate cancer [252], as well as normal cells under specific stress conditions (e.g., lipotoxicity in hepatocytes, [253]). The gene discussed is TNFRSF10B; the disease is Familial prostate cancer.