ESR1 and neuroblastoma: Computational analyses of differentially expressed miRNA–mRNA target associations predicted that the treatment of naïve rLEC with AZA might modulate cell proliferation supported by the downregulation of miR-18a-5p that could be linked to an upregulation of both CDKN1A and ESR1. Moreover, the downregulation of miR-18a has previously been shown to induce growth retardation in neuroblastoma cells via inhibition of ESR1 mRNA expression [29].