IGF1 and Hepatic fibrosis: Using Ingenuity Pathway Analysis Software, we found that these modulated genes are involved in the canonical pathways ‘Hepatic Fibrosis/Hepatic Stellate Cell Activation’, ‘PPARα/RXRα Activation’, ‘IGF-1 Signaling’, ‘VDR/RXR Activation’, ‘STAT3 Pathway’, ‘LXR/RXR Activation’, ‘PXR/RXR Activation’, ‘Glutathione-mediated Detoxification’, ‘Hepatic Cholestasis’, ‘BMP Signaling Pathway’, ‘Arginine Biosynthesis’ and ‘Hepatic Fibrosis Signaling Pathway’ (Figure S2).