MYC and metastatic colorectal cancer: Lv et al. demonstrated that miR-200b-3p was significantly downregulated in metastatic colorectal cancer, with the concomitant upregulation of c-Myc and PRDX2, suggesting the importance of the c-Myc/miR-200b/PRDX2 axis in colorectal cancer progression and the development of distant metastases [75].