A known mechanism of negative regulation of the Hippo pathway involves the E3 ubiquitin-protein ligase Itchy homolog (ITCH), which mediates Large Tumor Suppressor 1 (LATS1) ubiquitination and proteasomal degradation, leading to stabilization of dephosphorylated YAP/TAZ, and associating with tumorigenesis in several preclinical models including those of breast tumors [25,26]. The gene discussed is ITCH; the disease is breast neoplasm.