In parallel with cancer, an increasing number of emerging studies show that CFTR plays a role in fundamental cellular processes such as foetal development [4,5,6,7,8,9], epithelial differentiation/polarization [10,11,12,13,14], regeneration [15,16,17], and epithelial–mesenchymal transition (EMT) [18,19,20,21,22] (Figure 1). The gene discussed is CFTR; the disease is cancer.