CFTR and cystic fibrosis: This is supported by further studies revealing that wt-CFTR is intracellularly expressed in ciliated cells in a remodelled airway surface epithelium from non-CF individuals, thus demonstrating that airway remodelling and inflammation play critical roles in the differentiation state of the surface epithelium and consequently on CFTR apical localization in both CF and non-CF airways [11,12].