It has been reported that p66shc−/− cells, as well as various tissues in p66shc-knockout mice, are resistant to apoptosis induced by various different signals and pathological states, and that neuronal apoptotic cascades, including the release of cytochrome C and activation of caspase-3, occur in SNL-induced neuropathic pain [19,35,36,37]. The gene discussed is CASP3; the disease is neuropathic pain.