STAT3 and neoplasm: Since then, various reports substantiated STAT3′s engagement in promoting cancer hallmarks, such as tumor cell proliferation, evasion of apoptosis and angiogenesis by controlling the expression of pro-tumorigenic genes like Cyclin D1/2, c-MYC, MCL1, Survivin, BCL-XL, HGF, HIF-1α and VEGF [12,17,18,19,40,41].