M2-polarized tumor-associated macrophages (TAMs), myeloid derived suppressor (MDSC), regulatory T (Treg), type 17 CD4+ (Th17), type 2 CD4+ (Th2), B cells or cytokines such as IL-6, IL-10, IL-17, IL-23, are generally reported to be pro-tumorigenic. Here, IL6 is linked to neoplasm.