Here, STAT3 regulates NF-κB-dependent expression of tumor cell derived Chemokine (C-X-C motif) ligand 1 (the mouse orthologue to human IL-8) by sequestering NF-κB in the cytoplasm, thereby impairing pro-tumorigenic myeloid tumor infiltration and tumor vascularization [124]. Here, CXCL1 is linked to neoplasm.