Recently, an Fc-fusion EGFR decoy comprising the truncated extracellular domains of EGFR/ErbB-1 and ErbB-4 fused to Fc was shown to have high-affinity ligand binding to EGF-like growth factors and could inhibit the invasive growth and metastasis of mammary carcinoma cells [77]. The gene discussed is EGFR; the disease is breast carcinoma.